Selank is a synthetic heptapeptide (TKPRPGP) derived from tuftsin-related research, investigated experimentally in neurochemical, gene-expression, neuroimmune and stress-response research contexts.

Yes. Selank is a synthetic 7-amino-acid peptide (heptapeptide) with the sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro.

Is Selank the same as Semax?

No. Selank (TKPRPGP, tuftsin-derived) and Semax (MEHFPGP, ACTH(4-7)-derived) are chemically distinct peptides with different sequences, different parent peptides and different research literatures. They share only the terminal PGP motif.

What types of research involve Selank?

Experimental neurotransmitter-signalling, gene-expression, neuroimmune and stress-response research, largely in animal and laboratory models.

Is PepDirect Selank intended for human use?

No. Selank is supplied strictly as a laboratory research material. It is not marketed as a medicine, food supplement or product for human or veterinary use.

↳ Research overview

What Is Selank?

Selank is a synthetic heptapeptide derived from tuftsin-related research and developed at the Russian Academy of Medical Sciences. It has been investigated in neurochemical, gene-expression, neuroimmune and experimental stress-response research.

This guide covers Selank's identity, its relationship to tuftsin and the shape of the published evidence, no consumer-outcome framing.

For laboratory research context only. PepDirect supplies Selank as a research material, not for human or veterinary use.

§ Identity

What is Selank?

Selank is a synthetic heptapeptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro, TKPRPGP) whose N-terminal region corresponds to the tuftsin tetrapeptide (TKPR) with a C-terminal Pro-Gly-Pro (PGP) extension. The PGP extension was added by the original developers to increase enzymatic stability relative to native tuftsin.

Compound: Selank (synthetic heptapeptide)
Sequence: Thr-Lys-Pro-Arg-Pro-Gly-Pro (TKPRPGP)
Length: 7 amino acids (heptapeptide)
PubChem CID: 11765600

Lot-specific identity, purity and any additional identifiers should always be verified against the printed lot number and its corresponding Certificate of Analysis.

§ vs Tuftsin

How is Selank related to tuftsin?

Tuftsin is a naturally occurring tetrapeptide (Thr-Lys-Pro-Arg) generated from the Fc region of immunoglobulin G and historically studied in immunoregulatory research. Selank's N-terminal four residues correspond to the tuftsin sequence; the PGP extension is a synthetic addition intended to slow enzymatic degradation.

Selank is not tuftsin. Its research literature is separate from the classical tuftsin literature, Selank is characterised as a distinct synthetic peptide with its own experimental profile.

§ Research

What has Selank research investigated?

Neurotransmitter signalling, experimental studies involving GABAergic and monoamine pathways in animal models.
Gene-expression studies, reported effects on brain gene-expression profiles in rodent research.
Neuroimmune research, historical work exploring the cytokine and immunoregulatory context of tuftsin-related peptides.
Experimental stress-response models, behavioural and neurophysiological endpoints in rodent research.

The research contexts above are areas of published investigation. They do not establish anxiolytic, nootropic, focus-enhancing or mood-improvement outcomes in humans.

§ vs Semax

Selank vs Semax

Selank and Semax are both synthetic Russian-origin heptapeptides ending in a Pro-Gly-Pro (PGP) motif and are frequently discussed together in review literature. Chemically they are distinct, different sequences, different parent peptides, different research profiles. See the dedicated Semax vs Selank guide for the side-by-side comparison.

§ Not the same

Are Selank and Semax the same peptide?

No. Selank is TKPRPGP (tuftsin-derived); Semax is MEHFPGP (ACTH(4-7)-derived). They share only the terminal PGP motif, added independently in each case for enzymatic stability. Their research literatures should not be treated as interchangeable.

§ Evidence

How strong is the Selank evidence?

Mechanistic / laboratory evidence, includes receptor-binding and cellular-signalling work.
Animal / preclinical evidence, dominates the published corpus; includes behavioural, neurochemical and gene-expression studies in rodent models.
Human research, limited in scale and largely originates from a small research community; independent replication is limited.

PepDirect does not describe Selank as an established treatment for anxiety, stress or any clinical condition.

§ Research product

View the Selank research product

Selank is supplied by PepDirect as a lyophilised research material with lot-specific documentation.

View Selank Research Peptide →

§ References

Selected research references

Selank · PubChem CID 11765600 (heptapeptide TKPRPGP)PubChem (NCBI)
Regulatory peptide Selank, behavioural studies in animal modelsPubMed · Kozlovskii et al.
Semax and Selank, comparative research on Russian regulatory peptidesPubMed · Medvedev et al.
Tuftsin, immunoregulatory tetrapeptide research reviewPubMed · Najjar & Nishioka

§ FAQ

Frequently asked questions

What is Selank?: Selank is a synthetic heptapeptide (TKPRPGP) derived from tuftsin-related research, investigated experimentally in neurochemical, gene-expression, neuroimmune and stress-response research contexts.
Is Selank a peptide?: Yes. Selank is a synthetic 7-amino-acid peptide (heptapeptide) with the sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro.
How is Selank related to tuftsin?: Selank's first four residues (Thr-Lys-Pro-Arg) correspond to the tuftsin tetrapeptide sequence. A synthetic Pro-Gly-Pro extension is added to the C-terminus to improve enzymatic stability.
Is Selank the same as Semax?: No. Selank (TKPRPGP, tuftsin-derived) and Semax (MEHFPGP, ACTH(4-7)-derived) are chemically distinct peptides with different sequences, different parent peptides and different research literatures. They share only the terminal PGP motif.
What types of research involve Selank?: Experimental neurotransmitter-signalling, gene-expression, neuroimmune and stress-response research, largely in animal and laboratory models.
Is PepDirect Selank intended for human use?: No. Selank is supplied strictly as a laboratory research material. It is not marketed as a medicine, food supplement or product for human or veterinary use.

§ Related