↳ Research overview
What Is Semax?
Semax is a synthetic heptapeptide derived from the ACTH(4-7) sequence with a Pro-Gly-Pro extension. It has been studied in neurobiology research involving neurotrophic signalling, gene expression and neurotransmitter systems.
Much of the mechanistic evidence comes from preclinical and experimental models, and findings should not automatically be interpreted as established clinical outcomes.
For laboratory research use only. PepDirect supplies this material in laboratory formats only.
§ Identity
What Is Semax?
Semax is a synthetic seven-residue peptide developed in Russian neuroscience research. It is not a naturally occurring peptide, the sequence is an engineered fragment of adrenocorticotropic hormone (ACTH) extended at the C-terminus with a Pro-Gly-Pro (PGP) motif intended to increase enzymatic stability.
§ Peptide sequence
Semax Peptide Sequence
- Sequence: Met-Glu-His-Phe-Pro-Gly-Pro (MEHFPGP)
- Origin: ACTH(4-7) fragment (Met-Glu-His-Phe) plus a C-terminal Pro-Gly-Pro extension
- Heptapeptide (seven amino acids)
§ Derivation
How Was Semax Derived?
Semax was designed by combining the ACTH(4-7) fragment, the region associated with the non-hormonal, neurotropic activity of ACTH, with a Pro-Gly-Pro C-terminal extension intended to improve enzymatic stability. This design places Semax in the broader family of engineered ACTH-fragment analogues investigated in neurobiology research.
§ Research themes
What Is Semax Studied For?
- BDNF-related signalling research
- NGF and other neurotrophic-factor pathways
- Gene-expression research in neural tissue
- Dopaminergic signalling research
- Serotonergic signalling research
- Experimental neuroprotection models
These are research areas explored in cellular and preclinical models. They are not statements of demonstrated benefits for intelligence, memory, focus or the treatment of any disease.
§ Evidence
How Strong Is the Evidence?
Semax has been studied primarily in Russian preclinical and clinical literature. Cellular and animal studies form the majority of the mechanistic evidence base, with additional human literature in specific national research contexts.
Regulatory approval status varies by jurisdiction and should not be generalised. A regulatory approval in one country does not constitute UK medicinal approval. Evidence should be interpreted with attention to model type (cell / animal / human) and geographic/regulatory context.
§ Comparative
Semax vs Selank
Semax and Selank are both synthetic peptides originating from Russian neuroscience research, but they are distinct compounds with different sequences, different receptor/pathway research profiles and different histories. A dedicated Semax-vs-Selank guide is planned; this short comparison exists only to signal that the two are not interchangeable.
§ Research product
View the Semax research product
PepDirect supplies Semax as lyophilised research material with lot-specific documentation.
§ References
Selected research references
- Semax · PubChem CID 9811102 (heptapeptide MEHFPGP)PubChem (NCBI)
- Semax, an ACTH(4-10) analogue, induces BDNF and trkB mRNA in the rat basal forebrain (animal study)PubMed · Dolotov et al.
- Neurotrophin (BDNF/NGF) expression research in rat glial cultures (cellular study)PubMed · Shadrina et al.
- Semax and its C-terminal tripeptide PGP, genome-wide expression researchPubMed · Medvedeva et al.
§ FAQ
Frequently asked questions
- What is Semax?
- Semax is a synthetic heptapeptide derived from the ACTH(4-7) sequence with a Pro-Gly-Pro extension. It is investigated in neurobiology research.
- What is the Semax peptide sequence?
- Met-Glu-His-Phe-Pro-Gly-Pro (MEHFPGP).
- Is Semax derived from ACTH?
- Yes. Semax is based on the ACTH(4-7) fragment with a C-terminal Pro-Gly-Pro extension intended to improve enzymatic stability.
- What areas of research involve Semax?
- Reported research areas include BDNF and other neurotrophic-factor signalling, gene-expression research, dopaminergic and serotonergic signalling, and experimental neuroprotection models.
- Is Semax the same as Selank?
- No. Semax and Selank are distinct synthetic peptides with different sequences and different research profiles.
- Is PepDirect Semax intended for human use?
- No. PepDirect supplies Semax as a laboratory research product only. It is not marketed as a medicine, food supplement, cosmetic or product for human or veterinary use.
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