Retatrutide Raw Vial

§ About Retatrutide

§ The three receptors, GLP-1R, GIPR, GCGR

Retatrutide is investigated in laboratory research as a simultaneous agonist of three receptors from the metabolic-hormone / incretin signalling family: the glucagon-like peptide-1 receptor (GLP-1R), the glucose-dependent insulinotropic polypeptide receptor (GIPR), and the glucagon receptor (GCGR). This distinguishes it from single-receptor (GLP-1R only) and dual-receptor (GLP-1R + GIPR) research peptides in the same class.

§ Scientific Specifications

Compound Name

Retatrutide (LY3437943)

CAS Number

2381089-83-2

Molecular Formula

C221H342N46O68

Molecular Weight

4731.33 g/mol

Amino Acid Count

39-residue engineered peptide

Purity

99%+ (HPLC verified per lot)

Form

Lyophilized powder

Storage

Store dry, 2°C to 8°C

§ Preclinical & Laboratory Research Context

• Triple GLP-1R / GIPR / GCGR receptor agonism research
• Comparative research against dual GLP-1R/GIPR agonists (e.g. tirzepatide-class peptides)
• Incretin-pathway signalling studies in cellular and preclinical models
• Energy-expenditure and glucose-regulation research readouts
• Peptide engineering and receptor-selectivity investigations

§ Quality & Batch Testing

§ Research References

• Retatrutide (LY3437943), Triple hormone-receptor agonist research overviewPubMed · Rosenstock et al.
• Pharmacological characterisation of LY3437943, a novel triple GLP-1, GIP and glucagon receptor agonistPubMed · Coskun et al.
• Retatrutide, Phase 2 laboratory research readouts in metabolic pathway signallingPubMed · Jastreboff et al.
• GLP-1, GIP and glucagon receptors, incretin and metabolic signalling reviewPubMed · Müller et al.

§ FAQ

What is retatrutide studied for in research?

Laboratory and preclinical research has examined retatrutide as a triple agonist of the GLP-1, GIP and glucagon receptors. Reported research contexts include incretin-pathway signalling, energy-expenditure readouts, and glucose-regulation pathways in cellular and animal models. Findings are experimental and should not be interpreted as demonstrated therapeutic effects in humans.

How does retatrutide differ from tirzepatide or semaglutide?

Semaglutide is studied as a single agonist of the GLP-1 receptor. Tirzepatide is studied as a dual agonist of the GLP-1 and GIP receptors. Retatrutide is engineered to engage a third receptor, the glucagon receptor (GCGR), in addition to GLP-1R and GIPR, giving it a triple-receptor profile in laboratory research.

What are the three receptors retatrutide targets?

Retatrutide is investigated as an agonist of the glucagon-like peptide-1 receptor (GLP-1R), the glucose-dependent insulinotropic polypeptide receptor (GIPR), and the glucagon receptor (GCGR). All three are receptors in the metabolic-hormone / incretin signalling family.

What form does the Retatrutide Raw Vial ship in?

The Retatrutide Raw Vial ships as a lyophilised (freeze-dried) powder in a sealed vial. It must be reconstituted with an appropriate diluent before laboratory use. A lot-specific Certificate of Analysis is published on this product page and ships in the box.

Is retatrutide sold by PepDirect for human use?

No. PepDirect supplies retatrutide as a laboratory research format only. It is not marketed as a medicine, food supplement, cosmetic or product for human or veterinary use.

What amounts of Retatrutide does PepDirect supply?

PepDirect currently supplies Retatrutide in the following amounts: 10mg and 20mg and 40mg. The active selection on this page controls price and stock.

How is PepDirect Retatrutide tested?

Retatrutide is tested by HPLC to a purity of ≥ 99.5%. The current lot displayed on this page is TM-2427. A lot-specific Certificate of Analysis is published on the product page before purchase and ships in the box.

Is this intended for human use?

No. All PepDirect products are sold strictly for laboratory and research use only, and are not intended for human or veterinary use, consumption, or any clinical or diagnostic application.

How quickly does PepDirect ship?

Orders placed before 3:00 PM GMT are dispatched the same business day. Orders placed after 3:00 PM GMT are dispatched the next business day, with tracked delivery in 1-2 business days across the UK and EU. Shipping is calculated and shown at checkout based on destination.

Does PepDirect provide a Certificate of Analysis?

Yes. Every lot's COA is published on the product page before it ships, and the same PDF is included in the box.

What is your guarantee?

Same-day replacement on damaged or lost shipments, or a full refund on request, no questions asked.

§ Intended Use

This product is intended strictly for laboratory research applications by qualified personnel. It is not approved for human or animal consumption, and must not be used in foods, drugs, supplements, cosmetics, or diagnostics.

§ Related Research Compounds

• Retatrutide 40mg Pen Kit
• Cagrilintide
• AOD-9604
• NAD+

• Learn: What is Retatrutide? →

§ Legal Disclaimer

This compound and the statements on this page have not been evaluated by any regulatory body. No claims are made regarding diagnosis, treatment, mitigation, or prevention of any disease. Use is restricted to qualified researchers operating in appropriate laboratory environments.

§ Terms of Sale

By purchasing this product, the buyer confirms they are a qualified researcher or institutional purchaser, and accepts full responsibility for its handling, storage, and lawful use.