'CJC-1295' names a family of research peptides derived from the GHRH 1-29 sequence with stability-enhancing modifications. Two chemically different materials share the name: with-DAC and without-DAC (Modified GRF 1-29).

What does DAC mean in CJC-1295?

Drug Affinity Complex, a reactive group designed to bind covalently to serum albumin, extending pharmacokinetic persistence in research contexts.

Is CJC-1295 with DAC the same as no DAC?

No. They share the same modified GRF(1-29) backbone but differ chemically, DAC-modified peptide vs unmodified peptide. Their CAS numbers, molecular formulas, molecular weights and pharmacokinetic profiles are not identical.

Is Modified GRF(1-29) the same as CJC-1295 with DAC?

No. Modified GRF(1-29) is the same peptide commonly labelled CJC-1295 No DAC, the tetra-substituted GRF(1-29) analogue without the DAC modification. It is not the DAC-containing analogue.

Is CJC-1295 the same as Ipamorelin?

No. CJC-1295 is a GHRH analogue. Ipamorelin is a pentapeptide ghrelin/GHS-R agonist. They are chemically and pharmacologically distinct compounds.

Which CJC form is used in HULK?

The current HULK blend uses CJC-1295 without DAC (Modified GRF 1-29), paired with Ipamorelin. Verify against the current product page and lot Certificate of Analysis before use.

Are PepDirect CJC products intended for human use?

No. All PepDirect CJC-1295 research materials are supplied strictly for laboratory research use only. They are not marketed as medicines, food supplements or products for human or veterinary use.

↳ Research overview

What Is CJC-1295?

'CJC-1295' is a name used across the peptide-research market to describe two chemically different research materials, CJC-1295 with DAC and CJC-1295 without DAC (Modified GRF 1-29). This guide covers CJC-1295 as a research family and explains why the exact chemical identity of what is labelled 'CJC-1295' matters.

For the full structural / mechanistic comparison of the two forms, see the CJC-1295 DAC vs No DAC guide.

For laboratory research context only. PepDirect supplies CJC-1295 research materials, not for human or veterinary use.

§ Identity

What is CJC-1295?

CJC-1295 refers to research peptides derived from the growth-hormone-releasing hormone (GHRH) 1-29 sequence with additional stability-enhancing modifications. Two distinct chemical materials share the name in market usage:

CJC-1295 with DAC, GHRH 1-29 analogue plus a Drug Affinity Complex intended to promote reversible albumin association.
CJC-1295 without DAC, also commonly called Modified GRF (1-29) or 'tetrasubstituted GRF(1-29)'; carries the same tetra-substitutions but no DAC.

Because both materials are casually labelled 'CJC-1295' in the peptide-research market, buyers should always verify the specific identity, DAC-modified vs no-DAC / Modified GRF (1-29), via the printed lot number and its corresponding Certificate of Analysis.

§ GHRH

What is GHRH?

Growth-hormone-releasing hormone (GHRH) is an endogenous 44-amino-acid neuropeptide produced by the hypothalamus that stimulates the anterior pituitary to release growth hormone. GHRH (1-29), the N-terminal 29-residue fragment, retains the biological activity of full-length GHRH and is the sequence around which CJC-1295 research analogues are built.

§ DAC

What does DAC mean?

DAC stands for Drug Affinity Complex, a reactive chemical group appended to the peptide that is designed to bind covalently to a lysine residue on serum albumin. That albumin association is the design mechanism by which the modified peptide is intended to persist longer in circulation for pharmacokinetic research than an unmodified GHRH analogue.

Longer pharmacokinetic persistence is a research-design property. It is not a statement about laboratory-use frequency and PepDirect does not publish administration guidance.

§ DAC vs No DAC

CJC-1295 with DAC vs without DAC

The DAC-containing analogue and the peptide commonly labelled 'CJC-1295 No DAC' (Modified GRF 1-29) share the same tetra-substituted GRF(1-29) backbone but differ chemically, DAC-modified analogue vs unmodified peptide. Their molecular formulas, molecular weights, CAS numbers and pharmacokinetic research profiles are not identical.

The dedicated comparison guide below covers the structural, chemical-identity and pharmacokinetic-design differences in full.

§ Not identical

Is CJC-1295 No DAC the same molecule as CJC-1295 with DAC?

No. Although both are studied in GHRH-pathway research, they are distinct chemical materials. Naming ambiguity in the peptide-research market means the same 'CJC-1295' label is applied to both, which is why exact identity, checked against a lot-specific COA, is essential.

The relevant chemical identity for a given lot should always be confirmed against its Certificate of Analysis before research use.

§ vs Ipamorelin

CJC-1295 and Ipamorelin

CJC-1295 (both DAC and no-DAC forms) and Ipamorelin are frequently discussed together in growth-hormone-secretagogue research because they act at different, complementary points in the same broad endocrine pathway. Chemically and mechanistically they are distinct:

CJC-1295, GHRH analogue (acts at the GHRH receptor).
Ipamorelin, pentapeptide GHS-R (ghrelin receptor) agonist.

PepDirect does not claim synergistic outcomes between compounds in the absence of research on the exact combined preparation.

§ In HULK

CJC-1295 in the HULK blend

PepDirect's current HULK research blend contains CJC-1295 without DAC (Modified GRF 1-29), not the DAC-modified analogue, paired with Ipamorelin. Exact amounts and identifiers should always be verified against the current HULK product page and the lot-specific Certificate of Analysis before research use.

§ Research product

View the CJC-1295 research products

PepDirect supplies CJC-1295 with DAC and CJC-1295 without DAC as separate research materials with lot-specific documentation.

View CJC-1295 with DAC →

§ References

Selected research references

CJC-1295 (DAC), pharmacokinetic characterisation researchPubMed · Teichman et al.
GHRH receptor pharmacology, reviewPubMed · Mayo et al.
Modified GRF (1-29), analogue design and stability researchPubMed · Frohman et al.

§ FAQ

Frequently asked questions

What is CJC-1295?: 'CJC-1295' names a family of research peptides derived from the GHRH 1-29 sequence with stability-enhancing modifications. Two chemically different materials share the name: with-DAC and without-DAC (Modified GRF 1-29).
What does DAC mean in CJC-1295?: Drug Affinity Complex, a reactive group designed to bind covalently to serum albumin, extending pharmacokinetic persistence in research contexts.
Is CJC-1295 with DAC the same as no DAC?: No. They share the same modified GRF(1-29) backbone but differ chemically, DAC-modified peptide vs unmodified peptide. Their CAS numbers, molecular formulas, molecular weights and pharmacokinetic profiles are not identical.
Is Modified GRF(1-29) the same as CJC-1295 with DAC?: No. Modified GRF(1-29) is the same peptide commonly labelled CJC-1295 No DAC, the tetra-substituted GRF(1-29) analogue without the DAC modification. It is not the DAC-containing analogue.
Is CJC-1295 the same as Ipamorelin?: No. CJC-1295 is a GHRH analogue. Ipamorelin is a pentapeptide ghrelin/GHS-R agonist. They are chemically and pharmacologically distinct compounds.
Which CJC form is used in HULK?: The current HULK blend uses CJC-1295 without DAC (Modified GRF 1-29), paired with Ipamorelin. Verify against the current product page and lot Certificate of Analysis before use.
Are PepDirect CJC products intended for human use?: No. All PepDirect CJC-1295 research materials are supplied strictly for laboratory research use only. They are not marketed as medicines, food supplements or products for human or veterinary use.

§ Related