What does DAC mean in CJC-1295?

DAC stands for Drug Affinity Complex, the modification designed to associate with circulating albumin and alter the pharmacokinetic behaviour of the peptide.

Is CJC-1295 without DAC the same as Modified GRF (1-29)?

The material commonly sold as 'CJC-1295 No DAC' is generally described more precisely as Modified GRF (1-29). Strict scientific nomenclature treats these as the same free-base GHRH(1-29) analogue without the Drug Affinity Complex.

Are CJC-1295 with DAC and without DAC the same compound?

No. They are distinct chemical entities with different CAS numbers, molecular formulas and molecular weights. Only the DAC-bearing form carries the albumin-binding modification.

Why are their chemical identifiers different?

Adding the Drug Affinity Complex changes the molecular structure, adds mass, and changes the empirical formula, which in turn produces a distinct CAS number. That is why the two forms cannot share one identity block.

Can research on CJC-1295 with DAC be applied to Modified GRF (1-29)?

No. Pharmacokinetic evidence for the DAC-bearing form does not automatically apply to Modified GRF (1-29); the modification that produces the extended albumin-associated behaviour is absent in the No-DAC form.

Which form is used in PepDirect HULK?

HULK contains the No-DAC / Modified GRF (1-29)-type component together with Ipamorelin. Ingredient-level research should not be interpreted as evidence for the exact HULK blend formulation.

Are PepDirect research compounds intended for human use?

No. PepDirect supplies research compounds as laboratory research materials only. They are not marketed as medicines, food supplements or products for human or veterinary use.

↳ Research overview

CJC-1295 With DAC vs Without DAC

Products commonly labelled CJC-1295 with DAC and CJC-1295 without DAC differ structurally and should not be treated as interchangeable research materials. The DAC-containing compound carries an albumin-binding modification, while the material commonly marketed as 'without DAC' is generally Modified GRF (1-29).

'CJC-1295 without DAC' is widely used as a commercial name for Modified GRF (1-29), but strict scientific nomenclature distinguishes it from CJC-1295 itself. CJC-1295 refers to the DAC-bearing GHRH analogue containing the albumin-binding modification. Modified GRF (1-29) lacks that DAC moiety.

For laboratory research context only. Chemical identity affects CAS number, molecular formula and molecular weight, always refer to the lot-specific COA for the exact material supplied.

§ Terminology

What does DAC mean?

DAC stands for Drug Affinity Complex. In CJC-1295, the DAC modification was designed to interact with circulating albumin, altering the pharmacokinetic behaviour of the peptide relative to a GHRH-analogue that lacks the modification. Discussion of albumin association in the research literature applies specifically to the DAC-bearing form.

§ DAC form

CJC-1295 with DAC

CJC-1295 with DAC is a GHRH(1-29) analogue that carries the Drug Affinity Complex modification. Published pharmacokinetic research examining albumin-associated persistence has been performed on the DAC-bearing compound. That evidence is specific to this exact structure and cannot be freely transferred to the DAC-free variant.

§ No DAC form

"CJC-1295 Without DAC" / Modified GRF (1-29)

The material commonly sold as 'CJC-1295 No DAC' is more precisely described as Modified GRF (1-29). It corresponds to the GHRH(1-29) sequence with several stability modifications but does not carry the Drug Affinity Complex. Because it lacks the DAC moiety, its chemical identity, CAS number, molecular formula and molecular weight are different from those of the DAC-bearing compound, and DAC-form pharmacokinetic evidence does not automatically apply to it.

§ Comparison

Side-by-side comparison

Preferred scientific description, CJC-1295 (DAC) vs Modified GRF (1-29) (no DAC).
DAC moiety, Present vs Absent.
Albumin-binding design, Yes vs No.
CAS number, 446262-90-4 (DAC) vs 446036-97-1 (No DAC / Mod GRF 1-29).
Molecular formula, C165H269N47O46 (DAC) vs C152H252N44O42 (No DAC).
Molecular weight, ~3647.25 g/mol (DAC) vs ~3367.9 g/mol (No DAC).
Published human PK evidence for this exact form, Exists for the DAC form; do not infer from the DAC form for Modified GRF (1-29).

This table describes chemical identity and research context only. It contains no dosing, frequency or administration information.

§ Why it matters

Why terminology matters

Product identity governs CAS number, molecular formula and molecular weight. A Certificate of Analysis must correspond to the exact material being handled, 'with DAC' and 'without DAC' cannot share one chemical identity, and references cited on a product page must match the exact structure that lot represents.

§ In blends

Relationship to Ipamorelin and HULK

PepDirect's HULK research blend contains 5 mg of the No-DAC / Modified GRF (1-29)-type component alongside 5 mg of Ipamorelin. Ingredient-level research for either component should not automatically be represented as direct evidence for the exact HULK blend formulation. Blend-specific conclusions require research using the specific combined preparation.

§ Research product

View the CJC-1295 research products

PepDirect supplies both CJC-1295 with DAC and CJC-1295 No DAC as separate research materials with their own lot-specific documentation.

View CJC-1295 DAC Research Peptide →

§ References

Selected research references

CJC-1295 with DAC, GHRH analogue with albumin-binding modification (research overview)PubMed · Teichman et al.
CJC-1295 (DAC) sustained GH secretion, Phase I researchPubMed · Ionescu & Frohman
Growth-hormone releasing hormone analogues, receptor pharmacology reviewPubMed · Frohman & Kineman
Modified GRF (1-29) chemistry & the DAC-free analogue classPubMed · Alba & Salvatori

§ FAQ

Frequently asked questions

What does DAC mean in CJC-1295?: DAC stands for Drug Affinity Complex, the modification designed to associate with circulating albumin and alter the pharmacokinetic behaviour of the peptide.
Is CJC-1295 without DAC the same as Modified GRF (1-29)?: The material commonly sold as 'CJC-1295 No DAC' is generally described more precisely as Modified GRF (1-29). Strict scientific nomenclature treats these as the same free-base GHRH(1-29) analogue without the Drug Affinity Complex.
Are CJC-1295 with DAC and without DAC the same compound?: No. They are distinct chemical entities with different CAS numbers, molecular formulas and molecular weights. Only the DAC-bearing form carries the albumin-binding modification.
Why are their chemical identifiers different?: Adding the Drug Affinity Complex changes the molecular structure, adds mass, and changes the empirical formula, which in turn produces a distinct CAS number. That is why the two forms cannot share one identity block.
Can research on CJC-1295 with DAC be applied to Modified GRF (1-29)?: No. Pharmacokinetic evidence for the DAC-bearing form does not automatically apply to Modified GRF (1-29); the modification that produces the extended albumin-associated behaviour is absent in the No-DAC form.
Which form is used in PepDirect HULK?: HULK contains the No-DAC / Modified GRF (1-29)-type component together with Ipamorelin. Ingredient-level research should not be interpreted as evidence for the exact HULK blend formulation.
Are PepDirect research compounds intended for human use?: No. PepDirect supplies research compounds as laboratory research materials only. They are not marketed as medicines, food supplements or products for human or veterinary use.

§ Related