KPV is the tripeptide Lys-Pro-Val. It corresponds to the C-terminal three residues of alpha-MSH and is studied in preclinical models of inflammatory signalling, epithelial biology and peptide transport.

What pathways are studied in KPV research?

Reported research areas include NF-κB-related signalling, MAPK-related signalling, epithelial inflammatory models, intestinal research models, immune-cell signalling and PepT1 peptide-transport research.

Yes. KPV is one of four components of the KLOW research blend, alongside GHK-Cu, BPC-157 and TB-500.

Is PepDirect KPV intended for human use?

No. PepDirect supplies KPV as a laboratory research product only. It is not marketed as a medicine, food supplement, cosmetic or product for human or veterinary use.

↳ Research overview

What Is KPV?

KPV is the tripeptide Lys-Pro-Val and corresponds to the C-terminal three amino acids of alpha-melanocyte-stimulating hormone (alpha-MSH). It has been studied in experimental models involving inflammatory signalling, epithelial biology and peptide transport.

Most mechanistic evidence remains preclinical and should not be interpreted as established human therapeutic efficacy.

For laboratory research use only. PepDirect supplies this material in laboratory formats only.

§ Nomenclature

What Does KPV Stand For?

K = Lysine
P = Proline
V = Valine
Sequence: Lys-Pro-Val (a three-residue peptide)

§ Relationship

How Is KPV Related to Alpha-MSH?

Alpha-melanocyte-stimulating hormone (alpha-MSH) is a 13-residue peptide. Its C-terminal tripeptide, residues 11-13, has the sequence Lys-Pro-Val, i.e. KPV. Because of this relationship, KPV is often described as the C-terminal alpha-MSH tripeptide.

KPV is nonetheless distinct from the full alpha-MSH peptide. Research findings for full-length alpha-MSH should not be represented as findings for KPV, and vice versa.

§ Research themes

What Is KPV Studied For?

NF-κB-related signalling research
MAPK-related signalling research
Epithelial inflammatory experimental models
Intestinal research models
Immune-cell signalling
PepT1 peptide-transport research

These are described as research areas explored in cellular and animal models. They are not statements of demonstrated therapeutic outcomes for inflammatory bowel disease, skin conditions or any other clinical indication.

§ Evidence

How Strong Is the KPV Evidence?

The KPV literature is largely built on cellular studies and preclinical animal models. Direct human research evidence is comparatively limited.

When interpreting KPV research it is essential to distinguish between cell studies, animal models and human evidence, and to avoid extending in vitro or rodent findings directly to human outcomes.

§ Blends

KPV in the KLOW Blend

KPV is one component of PepDirect's KLOW research blend, alongside GHK-Cu, BPC-157 and TB-500. Evidence involving KPV alone should not automatically be interpreted as evidence for the exact KLOW formulation. Blend-specific conclusions require research using the specific combined preparation.

§ Research product

View the KPV research product

PepDirect supplies KPV as lyophilised research material with lot-specific documentation.

View KPV Research Peptide →

§ References

Selected research references

KPV · PubChem CID 125672 (Lys-Pro-Val tripeptide)PubChem (NCBI)
α-MSH C-terminal tripeptide KPV, anti-inflammatory tripeptide reviewPubMed · Kannengiesser et al.
Uptake of the anti-inflammatory tripeptide KPV in intestinal epithelial cells via PepT1PubMed · Dalmasso et al.
Melanocortin-derived tripeptide KPV attenuates inflammation in preclinical modelsPubMed · Brzoska et al.

§ FAQ

Frequently asked questions

What is KPV peptide?: KPV is the tripeptide Lys-Pro-Val. It corresponds to the C-terminal three residues of alpha-MSH and is studied in preclinical models of inflammatory signalling, epithelial biology and peptide transport.
What does KPV stand for?: K is Lysine, P is Proline, V is Valine. The sequence is Lys-Pro-Val.
How is KPV related to alpha-MSH?: KPV corresponds to residues 11-13 of alpha-melanocyte-stimulating hormone (alpha-MSH), its C-terminal tripeptide. However, KPV is a distinct compound from the full alpha-MSH peptide.
What pathways are studied in KPV research?: Reported research areas include NF-κB-related signalling, MAPK-related signalling, epithelial inflammatory models, intestinal research models, immune-cell signalling and PepT1 peptide-transport research.
Is KPV part of KLOW?: Yes. KPV is one of four components of the KLOW research blend, alongside GHK-Cu, BPC-157 and TB-500.
Does KPV research prove the effects of KLOW?: No. Ingredient-level evidence for KPV should not automatically be interpreted as evidence for the exact KLOW blend formulation.
Is PepDirect KPV intended for human use?: No. PepDirect supplies KPV as a laboratory research product only. It is not marketed as a medicine, food supplement, cosmetic or product for human or veterinary use.

§ Related