Are BPC-157 and TB-500 the same peptide?

No. They are distinct synthetic peptides with different sequences (15 amino acids vs 7 amino acids, acetylated), different parent proteins and different published research literatures.

BPC-157 is a 15-amino-acid peptide, a pentadecapeptide.

TB-500 is an acetylated 7-amino-acid fragment corresponding to residues 17–23 of thymosin beta-4 (N-acetyl-LKKTETQ).

Are BPC-157 and TB-500 used together in a blend?

Yes. PepDirect's Wolverine is a defined two-component research blend containing BPC-157 and TB-500. Evidence for either component alone does not automatically establish evidence for the combined blend.

Are PepDirect BPC-157 and TB-500 intended for human use?

No. Both are supplied strictly as laboratory research materials. They are not marketed as medicines, food supplements or products for human or veterinary use.

↳ Research overview

BPC-157 vs TB-500: Research Comparison

BPC-157 and TB-500 are two distinct synthetic peptides that are frequently discussed together in tissue-repair research literature. They are chemically unrelated, different sequences, different lengths, different parent proteins and different published evidence bases.

This guide separates the two peptides at the level of chemical identity so that research findings for one are not casually transferred to the other.

For laboratory research context only. PepDirect supplies both compounds as research materials, not for human or veterinary use.

§ BPC-157

What is BPC-157?

BPC-157 (Body Protection Compound-157) is a synthetic 15-amino-acid peptide, a pentadecapeptide, whose sequence was originally derived from a fragment of a human gastric-juice protein. It has been investigated primarily in preclinical and cellular research involving tissue-repair models, angiogenesis-related signalling and nitric-oxide-related pathways.

Reported chemical identity: C62H98N16O22, molecular weight ~1419.5 g/mol, CAS 137525-51-0, PubChem CID 9941957.

§ TB-500

What is TB-500?

TB-500 is an acetylated 7-amino-acid peptide fragment corresponding to residues 17–23 of thymosin beta-4. Its sequence is N-acetyl-Leu-Lys-Lys-Thr-Glu-Thr-Gln (N-acetyl-LKKTETQ) and it contains the LKKTETQ motif associated with actin-binding research.

Reported chemical identity: C38H68N10O14, molecular weight ~889.0 g/mol, CAS 885340-08-9, PubChem CID 62707662. TB-500 is chemically distinct from full-length thymosin beta-4 (a 43-residue protein), research on the intact protein should not be transferred to the fragment.

§ Comparison

Side-by-side comparison

Peptide length, 15 amino acids (BPC-157) vs 7 amino acids (TB-500, acetylated).
Parent origin, gastric-juice-protein-derived fragment (BPC-157) vs thymosin beta-4 17–23 fragment (TB-500).
Sequence, pentadecapeptide GEPPPGKPADDAGLV (BPC-157) vs N-acetyl-LKKTETQ (TB-500).
Molecular formula, C62H98N16O22 (BPC-157) vs C38H68N10O14 (TB-500).
Molecular weight, ~1419.5 g/mol (BPC-157) vs ~889.0 g/mol (TB-500).
CAS number, 137525-51-0 (BPC-157) vs 885340-08-9 (TB-500).
Research literature, separate evidence bases; findings for one should not be transferred to the other.

§ Rationale

Why are BPC-157 and TB-500 compared?

BPC-157 and TB-500 are paired in review literature and in research blends because both have been investigated in tissue-repair experimental models. That shared research theme is why the two names commonly appear together, not because they are chemically related.

PepDirect supplies both compounds individually and combined in the Wolverine research blend. Wolverine's evidence profile is not the same as the evidence profile of either component alone, blend-level conclusions require research on the exact blend.

§ Research themes

Research themes for each peptide

BPC-157, tissue-repair experimental models, angiogenesis-related signalling, nitric-oxide pathways, gastrointestinal models, tendon/ligament preclinical research.
TB-500, actin-binding research (via the LKKTETQ motif), thymosin-beta-4-fragment experimental research, tissue-repair preclinical models.

The research themes above are areas explored in cellular and animal models. They are not statements of demonstrated benefits in humans and are not endorsements of any human or veterinary use.

§ Mechanism

Do BPC-157 and TB-500 share the same research mechanism?

No. They may be paired in the same experimental context, tissue-repair research, but they are structurally unrelated peptides derived from different parent proteins with different research literatures. One mechanism should not be automatically assigned to the other.

§ TB-500 vs Tβ4

TB-500 is not full-length thymosin beta-4

This distinction matters when interpreting research citations. TB-500 is a short 7-residue acetylated fragment; full-length thymosin beta-4 is a 43-residue protein. They have different CAS numbers, molecular formulas and molecular weights. Research findings involving full-length thymosin beta-4 should not be treated as evidence for TB-500 unless the fragment itself was the studied material.

§ Research product

View the research products

BPC-157, TB-500 and the two-component Wolverine blend are supplied as separate research materials with lot-specific documentation.

View Wolverine Research Blend →

§ References

Selected research references

BPC-157 · PubChem CID 9941957 (pentadecapeptide)PubChem (NCBI)
TB-500 (acetylated Tβ4 17–23 fragment) · CAS 885340-08-9 identity recordFDA GSRS / precisionFDA
Stable Gastric Pentadecapeptide BPC 157 as a Therapy, reviewPubMed · Sikiric et al.
BPC 157 and Its Effects on Wound Healing and AngiogenesisPubMed · Chang et al.
Thymosin beta-4 (full-length), actin-sequestering research reviewPubMed · Goldstein et al.
Thymosin β4 fragments and actin-binding researchPubMed · Van Troys et al.

§ FAQ

Frequently asked questions

Are BPC-157 and TB-500 the same peptide?: No. They are distinct synthetic peptides with different sequences (15 amino acids vs 7 amino acids, acetylated), different parent proteins and different published research literatures.
How long is BPC-157?: BPC-157 is a 15-amino-acid peptide, a pentadecapeptide.
How long is TB-500?: TB-500 is an acetylated 7-amino-acid fragment corresponding to residues 17–23 of thymosin beta-4 (N-acetyl-LKKTETQ).
Is TB-500 the same as thymosin beta-4?: No. TB-500 is a short 7-residue acetylated fragment; full-length thymosin beta-4 is a 43-residue protein. They have different CAS numbers, molecular formulas and molecular weights, and research evidence for one should not be transferred to the other.
Why are BPC-157 and TB-500 compared?: Both peptides have been investigated in tissue-repair experimental research and are frequently paired in review literature and research blends. That shared research theme is why they commonly appear together, not because they are chemically related.
Do BPC-157 and TB-500 share the same research mechanism?: No. They are structurally unrelated, derived from different parent proteins, and their research literatures are separate. One mechanism should not be automatically assigned to the other.
Are BPC-157 and TB-500 used together in a blend?: Yes. PepDirect's Wolverine is a defined two-component research blend containing BPC-157 and TB-500. Evidence for either component alone does not automatically establish evidence for the combined blend.
Are PepDirect BPC-157 and TB-500 intended for human use?: No. Both are supplied strictly as laboratory research materials. They are not marketed as medicines, food supplements or products for human or veterinary use.

§ Related